Reversal of muscle atrophy by Zhimu-Huangbai herb-pair via Akt/mTOR/FoxO3 signal pathway in streptozotocin-induced diabetic mice.

Skeletal muscle atrophy is one of the serious complications of diabetes.Zhimu-Huangbai herb-pair (ZB) is widely used in Chinese traditional medicine formulas for treating Xiaoke (known as diabetes) and its complications.However, the effect of ZB on reversal of muscle atrophy and the underlying mechanisms remain unknown.In this research, we investig

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Quantifying the uncertainties of climate change effects on the storage-yield and performance characteristics of the Pong multi-purpose reservoir, India

Climate change is predicted to affect water resources infrastructure due to its effect on rainfall, temperature and evapotranspiration.However, there are huge uncertainties on both the magnitude and direction of these effects.The Pong reservoir on the Beas River in northern India serves irrigation and hydropower needs.The hydrology of the catchment

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